Riko and Reg begin their trek further down the Goblet of Giants, but as they press onward, they sense a presence moving along with them as they speak. They continue descending until they are confronted by an orbed piercer, and Reg prepares to face it until Riko reveals its spines are capable of piercing steel and poisoning their victims, putting Reg's life in danger as well. They attempt to escape, but the monster is able to read their movements and stop them, knocking Lyza's pickaxe out of their grasp and removing any means of defending themselves. Reg tries to stop the following attack with a scaled umbrella, but the spines pierce through not only the umbrella, but Riko's hand as well, injecting lethal poison in her system, forcing Reg to escape with her by ascending. This unfortunately results in Riko suffering the Fourth Layer's Curse: bleeding from every orifice. Coupled with the poison, Riko hallucinates as well, and she urges Reg to sever her arm to prevent the poison from going further. Though hesitant, he complies, but mid-way through the process, Riko stops breathing, and Reg, fearing the worst, falls into despair until a mysterious being tells him to remain calm and perform CPR, getting Riko breathing once more. They retreat into the hideout of the being, who reveals themselves as Nanachi.