"It will definitely have a ripple effect," executive producer Jed Whedon tells THR. "It is one world, so if there is a giant event, it will definitely have a ripple effect on our world." We'll have to wait and see if those ripple effects are equal to the effects of Captain America: The Winter Soldier, which practically flipped the show's concept on its head.
But whose side are the Agents of S.H.I.E.L.D. on?
"Lincoln wants to be a part of SHIELD, so as long as Coulson is the director of SHIELD, I'm sure that he's on Team Cap," Luke Mitchell says. "Therefore, Lincoln would be on Team Cap."
"I'm with you on that one [for Mack]," Henry Simmons added
"It’s a good question. I don’t know yet. I haven’t seen the film," Gregg says. "I think the Coulson from some of the earlier films, especially, would have just been, 'Wherever Steve Rogers goes, I’m going to be there with my cards, and at some point, I’m going to get them signed.' But what’s amazing about doing this character for 70 episodes of television, and putting him at the lead of a no-longer-existing SHIELD that’s hunted around the world, is that you get a very different perspective. I think it’s really going to depend, at such time as Coulson actually has to deal with what’s going on in the Marvel Cinematic Universe, on what has happened here, between now and then, because here is where his focus is right now."
"Hypothetically, you'd expect Fitz to be on the side of technology," Iain de Caestecker says.
"Simmons would be Iron Man, right?" Elizabeth Henstridge asks. "I think he could be Cap, right?"
"We're so scared doing interviews," Caestecker adds with a laugh.
"I'm Team Hunter," Nick Blood says. "I don't know whether Hunter would involve himself in those sort of politics."
"Whoever is closer to Thor," Ming-na Wen jokes.
Marvel's Agents of S.H.I.E.L.D. airs Tuesdays at 9 p.m. ET on ABC.
Check out when Captain America: Civil War and other movies are coming out in ComicBook.com's Movie Release Schedule.