The story has been reported to center around Marvel’s Civil War storyline, which saw heroes at odds both philosophically and later physically over a proposed Superhero Registration Act. The two factions in the comics were led by Captain America and Iron Man, and Robert Downey, Jr. will play Tony Stark, the film’s primary antagonist.
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It’s been widely rumored that the Avengers lineup will be significantly shaken up by the events of Avengers: Age of Ultron, a clip from which will debut on Marvel’s Agents of S.H.I.E.L.D. tonight.