Spoilers ahead for 40-year-old comics and, potentially but not certainly, The Amazing Spider-Man 2.
We finally get some context for the whole "traffic jam" joke that's been in every trailer here, including what it was Peter was late for...and some very down-to-earth stakes-setting: It isn't about whether or not Gwen will reprise her role from The Amazing Spider-Man #121, but whether their relationship can weather a move to London by Emma Stone's character so that she can follow her Oxford dreams.
In the comics, Spider-Man ends up haunted by Gwen's death because, after returning from a semester abroad, she's caught in a deadly battle between the hero and the Green Goblin. Are they really setting up the same here--a death for Gwen in The Amazing Spider-Man 3? It would explain why Mary Jane Watson was written out of this movie, perhaps.
What seems more likely is that he'll face a different kind of guilt: what's what she's wearing as she gets out of the taxi?
The Amazing Spider-Man 2 will be in theaters on May 2.