"Make It Reign" starts with Selena and the Daughters of the Night arriving at the Fortress of Sanctuary. There, they great Coville.
On Argo, Kara and Mon-El are investigating Selena's sudden disappearance. They try finding out a way to contact the DEO to warn them about Selena.
Ruby wakes up Sam up. Ruby realizes her mother is getting sick and she tries convincing her to seek medical help. Sam tries convincing Ruby that she'll get Lena and Alex to fix her for good.
Kara and Alura find a hologram crystal in Selena's living quarters and it powers up, displaying a hologram of Selena. Selena and Alura argue before Selena reveals she's rigged her former home with explosives. The explosives detonate and Kara's friend is seriously injured.
Sam is undergoing testing at the DEO and Lena tells her that her white blood cells are apparently reverting back to their previous Kryptonian state. Lena mentions that they're oxygen-deprived and Ruby suggests that maybe they charge the cells with the sun.
Winn reveals some of the non-lethal
The group on Argo comes to the conclusion that Selena could have been working on a portal of some sort.
On Earth, Coville and the Daughters of the Night begin a ritual to summon the real Reign to Earth. Reign's body won't fully form and Selena mentions they need the blood of the other two Worldkillers to complete the ritual. Coville says he knows where they can find the blood and we see the vials of blood are being stored at the DEO.
Winn's continuing his work on finishing his end of the transmat portal when Selena and her compatriots break into the DEO and start wrecking havoc. Alex begins fighting two of the Kryptonians when the third goes off to find Winn. She knocks Winn out in an attempt to find the vials of blood.
With Alex fighting with Selena, the last Kryptonian tries to locate Sam but Ruby hides the holding cell they're in so they can't be seen.
Alex runs in and uses kryptonite bullets against Selena but it's not effective. Kara's able to use Alura's hologram to trick one of the
Kara gives the Kryptonians the blood of Purity and Pestilence for them to stop their havoc on the DEO. They leave. Lena mentions
The Kryptonians return to the Fortress of Sanctuary and complete their part of the ritual, apparently recreating Reign.
Lena reveals that Reign is apparently back and as she gets stronger, Sam gets weaker. Mon-El recommends that they need some way to make Sam stronger so that Reign grows weaker.
They begin a procedure on Sam to transfer her consciousness back in the Dark Valley dimension. As they begin to transfer her, the rogue Kryptonians and Reign start an earthquake in the city.