Mr. & Mrs. Smith: All the Guest Stars in Season 1

Alexander Skarsgard and Eiza Gonzalez

Skarsgard and Gonzalez appear in the first episode of Mr. & Mrs. Smith — in fact, they are the characters that open the episode. The actors play (a version) of John and Jane (though viewers may not be immediately aware of that). The couple is seemingly hiding out together in a house somewhere rural, enjoying the quiet and seeming to be making some plans for their future when their peaceful idyll is disrupted by the arrival of mysterious assailants. The pair decide that they are tired of running and decide to face things once and for all. Unfortunately, both are killed and their deaths set the tone for the viewer in terms of just how dangers of a world the John (Glover) and Jane (Erskine) we'll get to know are about to be a part of.

Paul Dano

Showing up the first time in Episode 2, Dano plays Harris, the Smith's neighbor who seems to know way too much about them and their brownstone. For most of the season, it seems that he might be a rival spy, but it turns out that Harris is actually a nosy and slightly pushy real estate agent who really, really wants that brownstone. He survives the season, though not before being held at gunpoint by John in Episode 8. Last we see of Harris, he's seen going into the Smith's brownstone the morning after there has been a major confrontation (we'll get to that more later) and then calls his boss to tell them that the Smith's might be ready to sell.

John Turturro

Another Episode 2 guest star, Turturro plays Eric Shane. Shane turns out to be a billionaire that is the target of one of John and Jane's first mission when they're sent to administer truth serum to him at a high-end silent art auction and then record everything he says without witnesses or casualties.

Unfortunately for Shane, the mission ends up being a failure for the Smiths. John and Jane both end up dosing him with truth serum and he ends up having a very, very bad reaction to it. He blurts out a number of s major and damaging secrets at the art auction and the pair quickly get him out of there, but the man dies from the double dose of the serum on their kitchen floor, which forces the pair to have to dispose of his corpse on their own — and means they've failed their first mission.

Sharon Horgan and Billy Campbell

Appearing in Episode 3, Horgan and Campbell play Gavol and Parker Martin, targets of John and Jane's third mission where the spies are tasked with keeping tabs on the unhappy couple while they're on a ski vacation in the Italian Dolomites. The mission is a turning point for the Smiths and their relationship in no small part because it is also a turning point for the Martins as well. Gavol is taken hostage, Parker opts not to pay the ransom, and while Gavol ends up surviving after being saved by John, it prompts her and Parker to reevaluate their relationship as Parker only realizes after he was willing to let her die just how much she means to him. Similarly, it's John nearly dying while trying to save Gavol that prompts Jane to realize that she's begun to develop real feelings for John.

Parker Posey and Wagner Moura

In Episode 4, viewers learn that there are more than just one set of Johns and Janes as we're introduced to Posey and Moura's Other Jane and Other John. They're working for the same group our John and Jane do. Hihi, but are higher level spies — they are a "super high risk" couple who have been working for Hihi for more than 15 years.

It also turns out that their job at the highest level is to kill other agents (you know, like the couple we saw in the opening). They come back in Episode 8 to kill John and Jane, but the episode (and season) ends in gunfire and no clear resolution of exactly who survives.

Ron Perlman

One of the most delightful cameos happens in Episode 5 with Perlman's Toby. Toby is someone that John and Jane are given the task of keeping alive which proves to be a challenge because of just how many attempts there are. He also behaves in a very childlike fashion which is entertaining for the viewer, but not so much for John and Jane. Toby survives as they get him to safety, but now they're questioning some of the things they want out of their relationship — like kids.

Sarah Paulson

Every complicated relationship (probably) needs therapy and that brings us to Sarah Paulson's therapist character in Episode 6. Kind and pleasant and maybe even a little crunchy, the therapist works to help encourage John and Jane to fix their marriage. The process gets them to understand themselves a bit better and make a major breakthrough about their relationship, but then things go sideways when she mentions recordings of the appointments.

Because John and Jane are spies, they end up destroying the therapist's house with fire in an attempt to destroy those recordings and records and thus, preserve themselves. After all, a spy has to keep certain secrets. The therapist survives, though.

Michaela Coel

Coel plays Bev, another of the Smith's neighbors. We meet her in Episode 7 and Jane ends up confronting Bev at one point when John starts spending too much time with her. However, while Harris is actually just a regular, albeit, nosy neighbor, Bev isn't so harmless. She's a spy for a rival agency. She manages to escape from John and Jane.