"I can't really," she explained yesterday at the 3, 2, 1... Frankie Goes Boom press junket. "I have my own show so I will not be a regular on the Marvel S.H.I.E.L.D. show. But I'm glad people are so excited about that. I think it's a good idea... Maybe I could do some little thing."
Superhero Hype picked up her remarks, and also reminded fans that Maximiliano Hernández, hinted that it's possible we'll see his Agent Jasper Sitwell as a member of the cast. That character appeared in Item 47, as well as Thor and The Avengers, and his IMDb page currently suggests he's in pre-production on S.H.I.E.L.D. as well.