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Joe Quesada has some words on that
With the conclusion of the Age of Ultron miniseries, Marvel Comics have laid the groundwork for a massive change to their multiverse, the likes of which the publisher has never seen before.It’s more in line, actually, with DC Comics’s Crisis on Infinite Earths, a story in which the vast multitudes of alternate earths get crushed under the bootheel of an event. That is, as many expected, why we saw the end of multiverse-traveling books like Age of Apocalypse and X-Treme X-Men coming just ahead of this concluding chapter.