The two characters already got close enough and did the horizontal dance in Jessica Jones' Netflix series, they went their separate ways by that show's final episode.
"I can tease you that there may or may not be something between them," Colter said at the Defenders panel at Comicpalooza (via It's All Connected). "I mean, it's great. You get to see Luke and Jessica together again on screen. Hopefully you'll all be satisfied seeing how it moves to another storyline."
Luke Cage is currently involved with Claire Temple, played by Rosario Dawson. The two started hooking up during the second half of his solo series. Her character will also be appearing in Defenders, and photos of the production have revealed their relationship is still going well.
It's definitely an interesting predicament for Cage, especially when you throw Misty Knight into the mix.
Keep in ming that Luke Cage and Jessica Jones are an item in the comics—married, with children, in fact. Though the Marvel Cinematic Universe's tends to be faithful to the comic book storylines, the films and TV shows are not beheld to them.
It will be interesting to see how all of the relationship drama plays out, but the Netflix series might go the route of making Cage and Jones "work friends" rather than lovers. Been there, done that. It'll be especially difficult when both characters are meant to star in their own series.
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Marvel's The Defenders is developed by Douglas Petrie and Marco Ramirez. The miniseries will also feature Sigourney Weaver as the villain, Alexandra (Sigourney Weaver), and several recurring guest stars from Marvel's Daredevil, Marvel's Jessica Jones, Marvel's Luke Cage, and Marvel's Iron Fist, including Eka Darville as Malcolm Ducasse, Simone Missick as Misty Knight, Deborah Ann Woll as Karen Page, Elden Henson as Foggy Nelson, Carrie-Anne Moss as Jeri Hogarth, Scott Glenn as Stick, Rachael Taylor as Trish Walker, Rosario Dawson as Claire Temple, and Jessica Henwick as Colleen Wing.